Synthetic oleanane triterpenoids: magic bullets or not?
نویسندگان
چکیده
منابع مشابه
Chemical and biological characterization of oleanane triterpenoids from soy.
Soyasaponins are a group of complex and structural diverse oleanane triterpenoids found in soy (Glycine max) and other legumes. They are primarily classified into two main groups - group A and B - based on the attachment of sugar moieties at positions C-3 and C-22 of the ring structures. Group A soyasaponins are bidesmosidic, while group B soyasaponins are monodesmosidic. Group B soyasaponins a...
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In continuation of our research to find biological components from Panax stipuleanatus, four oleanane-type triterpenes (12 to 15) were isolated successively. Fifteen oleanane-type saponins (1 to 15) were evaluated for nuclear factor (NF)-κB activity using a luciferase reporter gene assay in HepG2 cells. Compounds 6 to 11 inhibited NF-κB, with IC50 values between 3.1 to 18.9 μM. The effects on i...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2013
ISSN: 0085-2538
DOI: 10.1038/ki.2013.38